Opportunity Information: Apply for RFA DA 19 009
The National Institutes of Health (NIH) released this R01 funding opportunity (RFA-DA-19-009), titled "Modeling HIV Neuropathology Using Microglia from Human iPSC and Cerebral Organoids (Clinical Trial Not Allowed)," to support basic and translational research aimed at understanding why HIV-associated neurological disorders (HAND) persist even in the era of long-term combination antiretroviral therapy (cART). The central scientific goal is to uncover the cellular and molecular mechanisms that drive HIV-related neuropathophysiology under modern treatment conditions, using advanced human-based model systems rather than relying only on animal models or postmortem tissue. In practical terms, the FOA is looking for projects that use patient-derived induced pluripotent stem cell (iPSC) lines to generate induced microglia and human cerebral organoids, then leverage those platforms to study how HIV and its treatment environment affect brain-resident immune cells, neuron-glia interactions, inflammatory signaling, and downstream neural dysfunction relevant to HAND.
A key feature of the announcement is its emphasis on microglia and organoid systems as a way to model disease processes in a controlled, human-relevant context. Microglia are the brain’s primary innate immune cells and are increasingly understood as central players in neuroinflammation and synaptic/neuronal health. Cerebral organoids, meanwhile, provide a three-dimensional, multi-cellular environment that can approximate aspects of brain development and tissue organization. By combining induced microglia with cerebral organoids derived from patient iPSCs, applicants are expected to build experimental systems that can probe questions such as how chronic immune activation is maintained in the brain during suppressive therapy, how viral proteins or reservoirs might contribute to ongoing injury, how antiretroviral exposure intersects with inflammatory pathways, and what molecular signatures track with neurocognitive impairment. The opportunity is positioned to encourage mechanistic work that can clarify cause-and-effect relationships, identify pathways that could be targeted therapeutically, and improve the field’s ability to replicate key features of HAND in vitro.
This is an NIH discretionary grant mechanism in the R01 format, and it explicitly states "Clinical Trial Not Allowed," meaning the supported work should not include prospective human interventional clinical trials. The program sits within the broad health and education activity category and is associated with CFDA number 93.279. The original closing date listed for the opportunity was December 18, 2018, with a creation date of September 7, 2018. An award ceiling is not specified in the provided source information, and the number of expected awards is also not listed.
Eligibility is broad across U.S.-based organizational types typically allowed under NIH research grants. Eligible applicants include state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; Native American tribal organizations that are not federally recognized; public housing authorities/Indian housing authorities; nonprofit organizations with or without 501(c)(3) status (other than institutions of higher education); for-profit organizations (other than small businesses); small businesses; and other entities as NIH permits. The FOA also highlights additional eligible applicant categories such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), eligible federal agencies, faith-based or community-based organizations, regional organizations, and U.S. territories or possessions. At the same time, the opportunity clearly restricts foreign involvement: non-domestic (non-U.S.) entities and non-U.S. institutions are not eligible to apply, non-domestic components of U.S. organizations are not eligible, and foreign components (as NIH defines them in its Grants Policy Statement) are not allowed.
Overall, the FOA is aimed at moving the HAND field toward more precise human cellular models that reflect the realities of long-term cART, with microglia-centered and organoid-based approaches used to dissect mechanisms, map molecular pathways, and create platforms that could ultimately inform future therapeutic strategies (while staying within non-clinical trial research boundaries for this specific announcement).Apply for RFA DA 19 009
- The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Modeling HIV Neuropathology Using Microglia from Human iPSC and Cerebral Organoids (R01 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.279.
- This funding opportunity was created on 2018-09-07.
- Applicants must submit their applications by 2018-12-18. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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