Opportunity Information: Apply for PA 16 451
The Kidney Precision Medicine Project - Technology Development and Validation (R41/R42) funding opportunity (NIH FOA PA 16-451) is a discretionary NIH grant program designed specifically for small businesses that can build, refine, and validate technologies needed by the Kidney Precision Medicine Project (KPMP). At its core, the FOA is trying to pull innovation from the small business sector into a large national effort focused on understanding kidney disease at a much more precise, tissue- and cell-resolved level than what is typically possible in routine clinical care.
KPMP itself is described as a major initiative that will collect and evaluate kidney biopsies from people with acute kidney injury (AKI) and chronic kidney disease (CKD). The long-term scientific goal is to use those biopsies to construct a detailed kidney tissue atlas, sort patients into more biologically meaningful disease subgroups, and pinpoint the specific cells, molecular pathways, and potential therapeutic targets that drive different forms of kidney injury and progression. The practical implication is that KPMP is not simply collecting samples; it is building an integrated reference map of kidney disease biology that could enable more accurate diagnoses, better prediction of outcomes, and new treatment strategies grounded in mechanism rather than broad clinical labels.
Within that context, the FOA emphasizes technology development that either makes kidney biopsy safer or increases the amount and quality of information that can be extracted from human kidney tissue once it is obtained. In other words, proposed tools should help ensure that a biopsy yields high-value research or clinically relevant data. The announcement is oriented toward technologies that strengthen the pipeline from biopsy collection through tissue handling and interrogation, recognizing that kidney biopsies are precious, limited samples and that both patient safety and sample quality are central to KPMP success.
The grant mechanism referenced (R41/R42) indicates an SBIR phased approach, where Phase I (R41) is generally aimed at establishing feasibility and demonstrating early proof-of-concept, and Phase II (R42) supports further development and validation toward a more complete, deployable solution. The program is therefore well-suited to companies that can credibly move from a prototype or early technical concept into a validated technology that can be used in KPMP-style workflows and, potentially, in broader clinical or translational settings.
Eligibility is limited to small businesses. The FOA makes clear that non-U.S. (foreign) institutions are not eligible to apply as applicant organizations, and non-U.S. components of U.S. organizations are also not eligible to apply. However, it notes that foreign components, as defined under the NIH Grants Policy Statement, may be allowed in certain circumstances, which typically means some discrete portion of the work could occur outside the United States if it is well-justified and consistent with NIH policy, even though the applicant organization itself must be domestic and eligible.
Administratively, the opportunity is issued by the National Institutes of Health, is categorized under health-related funding activity (CFDA 93.847), and was originally created on 2016-09-28 with an original closing date listed as 2020-01-05. The source summary does not specify an award ceiling or the expected number of awards, so prospective applicants would normally need to consult the full FOA text or NIH SBIR guidance for budget structure, phase limits, and application details. Overall, the opportunity is best understood as NIH using the SBIR program to accelerate practical, validated technologies that make human kidney biopsy-based precision medicine safer, more informative, and more scalable for AKI and CKD research and, ultimately, patient care.Apply for PA 16 451
- The National Institutes of Health in the food and nutrition, health sector is offering a public funding opportunity titled "Kidney Precision Medicine Project - Technology Development and Validation (R41/R42)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.847.
- This funding opportunity was created on 2016-09-28.
- Applicants must submit their applications by 2020-01-05. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Small businesses.
[Watch] Creating a grant proposal using the step-by-step wizard inside the applicant portal:
Frequently Asked Questions (FAQs)
What is the funding opportunity?
This opportunity is The Kidney Precision Medicine Project - Technology Development and Validation (R41/R42) under NIH FOA PA 16-451. It is a discretionary NIH grant program using the SBIR phased mechanisms (Phase I R41 and Phase II R42) to support small businesses developing and validating technologies needed by the Kidney Precision Medicine Project (KPMP).
What is the main purpose of this FOA?
The FOA is intended to bring innovation from the small business sector into KPMP by funding technology development that helps make kidney biopsies safer and/or increases the amount and quality of information that can be obtained from human kidney tissue after it is collected.
What is KPMP (Kidney Precision Medicine Project)?
KPMP is a major national initiative focused on collecting and evaluating kidney biopsies from people with acute kidney injury (AKI) and chronic kidney disease (CKD). A long-term goal is to build a detailed kidney tissue atlas, define more biologically meaningful disease subgroups, and identify cells, molecular pathways, and potential therapeutic targets involved in kidney injury and progression.
Which patient populations or conditions are relevant to KPMP?
KPMP is described as collecting and evaluating kidney biopsies from individuals with acute kidney injury (AKI) and chronic kidney disease (CKD).
What kinds of technologies does the FOA emphasize?
The emphasis is on technologies that either (1) make kidney biopsy safer, or (2) increase the amount and quality of information extracted from human kidney tissue once it is obtained. The FOA is oriented toward strengthening the workflow from biopsy collection through tissue handling and interrogation.
Why does the FOA focus on the biopsy-to-data pipeline?
The FOA highlights that kidney biopsies are precious and limited samples, so both patient safety and sample quality are central. Technologies that improve how biopsies are collected, handled, or analyzed can help ensure each biopsy yields high-value research or clinically relevant data.
What does the R41/R42 mechanism mean for applicants?
R41/R42 indicates an SBIR phased approach. Phase I (R41) generally supports feasibility work and early proof-of-concept. Phase II (R42) supports further development and validation toward a more complete, deployable solution.
What stage of product development is this opportunity best suited for?
Based on the SBIR phased structure described, it is well-suited for companies that can move from a prototype or early technical concept (feasibility/proof-of-concept) into a validated technology that can be used in KPMP-style workflows and potentially broader clinical or translational settings.
Who is eligible to apply?
Eligibility is limited to small businesses. The opportunity is designed specifically for small businesses that can build, refine, and validate KPMP-relevant technologies.
Are non-U.S. (foreign) organizations eligible to apply as the applicant?
No. The FOA states that non-U.S. (foreign) institutions are not eligible to apply as applicant organizations.
Are non-U.S. components of U.S. organizations eligible?
No. The FOA states that non-U.S. components of U.S. organizations are also not eligible to apply.
Can any portion of the project take place outside the United States?
The summary notes that foreign components, as defined under the NIH Grants Policy Statement, may be allowed in certain circumstances. This typically means a discrete portion of the work could occur outside the U.S. if it is well-justified and consistent with NIH policy, while the applicant organization itself must be domestic and eligible.
Which agency is offering this grant opportunity?
The opportunity is issued by the National Institutes of Health (NIH).
How is this opportunity categorized?
It is categorized as a health-related funding activity and is associated with CFDA 93.847.
What is the overall scientific and practical goal behind the work KPMP supports?
Scientifically, KPMP aims to build an integrated reference map (a kidney tissue atlas) that resolves kidney disease at a tissue- and cell-specific level, enabling better biological subgrouping and identification of mechanisms and targets. Practically, this approach could support more accurate diagnoses, improved prediction of outcomes, and treatment strategies based on disease mechanisms rather than broad clinical labels.
Does the summary provide an award ceiling or expected number of awards?
No. The source summary does not specify an award ceiling or the expected number of awards. Applicants would typically need to consult the full FOA text or NIH SBIR guidance for budget structure, phase limits, and other application details.
When was the opportunity created and what closing date is listed?
The summary states the opportunity was originally created on 2016-09-28 and lists an original closing date of 2020-01-05.
What is the big picture of why NIH is using SBIR for this effort?
Overall, the opportunity is best understood as NIH using the SBIR program to accelerate practical, validated technologies that make human kidney biopsy-based precision medicine safer, more informative, and more scalable for AKI and CKD research and, ultimately, patient care.
Browse more opportunities from the same category: Food and Nutrition, Health
Next opportunity: NIST Summer Institute for Middle School Science Teachers (NIST Summer Institute) Program
Previous opportunity: DRL Applied Research and Evaluation Fund: Evidence-Based Evaluation of Approaches to Inclusive Human Rights in Ukraine
Applicant Portal:
Are you interested in learning about about how to apply for this government funding opportunity? You can create a free applicant account and receive instant access to our applicant portal that many business owners like you have benefited from.
Apply for PA 16 451
Applicants also applied for:
Applicants who have applied for this opportunity (PA 16 451) also looked into and applied for these:
| Funding Opportunity |
|---|
| Addressing Health Disparities in NIDDK Diseases (R01) Apply for PA 17 021 Funding Number: PA 17 021 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Circadian Mechanisms Contributing to Obesity, Diabetes Metabolism, and Underlying Heart, Lung, and Blood Disorders (R01) Apply for RFA HL 17 020 Funding Number: RFA HL 17 020 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $500,000 |
| NIDDK Exploratory Clinical Trials for Small Business (R44) Apply for PAR 17 034 Funding Number: PAR 17 034 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Pilot Clinical Trials in Pediatric Chronic Kidney Disease Data Coordinating Center (U24) Apply for RFA DK 16 035 Funding Number: RFA DK 16 035 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $350,000 |
| Pilot Clinical Trials in Pediatric Chronic Kidney Disease Participating Clinical Centers (U01) Apply for RFA DK 16 018 Funding Number: RFA DK 16 018 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $250,000 |
| APOL1 Long-term Kidney Transplantation Outcomes Network (APOLLO) Clinical Centers (Collaborative U01) Apply for RFA DK 16 025 Funding Number: RFA DK 16 025 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $200,000 |
| Limited Competition: Research Resource for Human Organs and Tissues (U42) Apply for RFA OD 17 001 Funding Number: RFA OD 17 001 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Limited Competition: Continuation of the Preventing Early Renal Loss in Diabetes (PERL) Study (UC4) Apply for RFA DK 16 506 Funding Number: RFA DK 16 506 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Silvio O. Conte Digestive Diseases Research Core Centers (P30) Apply for RFA DK 17 001 Funding Number: RFA DK 17 001 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $750,000 |
| Therapeutic Targeting Of The Human Islet Environment (UC4) Apply for RFA DK 17 003 Funding Number: RFA DK 17 003 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $600,000 |
| Competitive Collaborative Projects for Human Islet Biology (UC4) Apply for RFA DK 17 004 Funding Number: RFA DK 17 004 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $350,000 |
| Limited Competition: Follow-up on Subjects and Immunological Assessments in The Environmental Determinants of Diabetes In The Young Study (TEDDY) (UC4) Apply for RFA DK 16 504 Funding Number: RFA DK 16 504 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Biomarkers for Diabetes, Digestive, Kidney and Urologic Diseases Using Biosamples from the NIDDK Repository (R01) Apply for PAR 17 123 Funding Number: PAR 17 123 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $250,000 |
| Lead Optimization and Preclinical Development of Therapeutic Candidates for Diseases of Interest to the NIDDK (R41/R42) Apply for PA 17 131 Funding Number: PA 17 131 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Lead Optimization and Preclinical Development of Therapeutic Candidates for Diseases of Interest to the NIDDK (R43/R44) Apply for PA 17 130 Funding Number: PA 17 130 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Pragmatic Research in Healthcare Settings to Improve Diabetes and Obesity Prevention and Care (R18) Apply for PAR 17 177 Funding Number: PAR 17 177 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Evaluating Natural Experiments in Healthcare to Improve Diabetes Prevention and Treatment (R18) Apply for PAR 17 178 Funding Number: PAR 17 178 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $500,000 |
| Planning Grants for Pragmatic Research in Healthcare Settings to Improve Diabetes and Obesity Prevention and Care (R34) Apply for PAR 17 180 Funding Number: PAR 17 180 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $150,000 |
| Pragmatic Research in Healthcare Settings to improve Kidney Disease Prevention and Care (R18) Apply for RFA DK 17 008 Funding Number: RFA DK 17 008 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $325,000 |
| Limited Competition: Data Coordinating Center for Type 1 Diabetes TrialNet (UC4) Apply for RFA DK 17 507 Funding Number: RFA DK 17 507 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
Grant application guides and resources
It is always free to apply for government grants. However the process may be very complex depending on the funding opportunity you are applying for. Let us help you!
Apply for Grants
Inside Our Applicants Portal
Access Applicants Portal
- Grants Repository - Access current and historic funding opportunities with ease. Thousands of funding opportunities are published every week. We can help you sort through the database and find the eligible ones to apply for.
- Applicant Video Guides - The grant application process can be challenging to follow. We can help you with intuitive video guides to speed up the process and eliminate errors in submissions.
- Grant Proposal Wizard - We have developed a network of private funding organizations and investors across the United States. We can reach out and submit your proposal to these contacts to maximize your chances of getting the funding you need.
Premium leads for funding administrators, grant writers, and loan issuers
Thousands of people visit our website for their funding needs every day. When a user creates a grant proposal and files for submission, we pass the information on to funding administrators, grant writers, and government loan issuers.
If you manage government grant programs, provide grant writing services, or issue personal or government loans, we can help you reach your audience.
Learn More
Request more information:
Would you like to learn more about this funding opportunity, similar opportunities to "PA 16 451", eligibility, application service, and/or application tips? Submit an inquiry below:
Don't forget to subscribe to our grant alerts mailing list to receive weekly alerts on new and updated grant funding opportunities like this one in your email.