Opportunity Information: Apply for RFA HL 18 007
ImPlementation REsearCh to DEvelop Interventions for People Living with HIV (PRECluDE) (U01), Funding Opportunity Number RFA-HL-18-007, is a National Institutes of Health (NIH) cooperative agreement grant opportunity under the U.S. Department of Health and Human Services. The focus is on implementation research, meaning it is not primarily aimed at discovering new clinical interventions, but at figuring out how to deliver and scale interventions that are already proven to work. Specifically, the FOA targets people living with HIV/AIDS who also face co-occurring heart, lung, blood, and sleep (HLBS) diseases and related conditions, where effective prevention and management approaches already exist but are not being consistently used in real-world care.
The central problem the FOA is trying to solve is the persistent gap between evidence and practice. While clinical guidelines and effective interventions for common HLBS comorbidities in people with HIV are available, they have not been fully adopted across community and clinical settings. As a result, many patients do not receive recommended screening, prevention, and treatment services, or they receive them inconsistently. PRECluDE is designed to support projects that identify the practical, system-level, provider-level, and patient-level barriers that block uptake of these proven approaches, and then test strategies to overcome those barriers so that high-quality care becomes routine rather than exceptional.
A key emphasis is on late-stage translation research, described in the FOA as T4 translation. In plain terms, T4 work is about moving beyond whether an intervention works in controlled environments and focusing instead on how to embed it into everyday health systems at scale, sustain it over time, and reach the populations who need it most. Applications are expected to use implementation science approaches, which can include studying workflow redesign, provider training and decision support, care coordination models, clinic-community linkages, patient engagement strategies, policy or reimbursement-related levers, and other methods that directly address adoption, fidelity, reach, equity, sustainability, and real-world effectiveness.
The funding mechanism is a cooperative agreement (U01), which typically means NIH expects substantial involvement with awardees during the life of the project compared with a standard research grant. The opportunity was categorized as discretionary funding and sits within the health activity area. The award ceiling listed is $500,000, and the FOA anticipated making about five awards. The posted creation date is May 12, 2017, with an original closing date of August 7, 2017.
Eligibility is broad and includes many types of organizations that could realistically conduct community- and clinic-based implementation research. Eligible applicants include state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments and other tribal organizations; public housing authorities and Indian housing authorities; nonprofit organizations (both 501(c)(3) and non-501(c)(3)); for-profit organizations other than small businesses; small businesses; and other entities as allowed under the FOA’s additional eligibility language. In practice, this range reflects the FOA’s real-world orientation, since improving implementation often requires partnerships across health systems, public health agencies, community organizations, and other local stakeholders who influence access and care delivery.
Overall, PRECluDE is best understood as a call for pragmatic, partnership-driven research that helps proven HLBS interventions actually reach people living with HIV in the settings where they receive care. The intended outcome is not just more knowledge about comorbid HLBS conditions, but measurable improvements in how evidence-based prevention, control, and treatment strategies are delivered, scaled, and sustained for this population, closing gaps in care that persist despite the availability of effective guidelines and treatments.Apply for RFA HL 18 007
- The Department of Health and Human Services, National Institutes of Health in the health sector is offering a public funding opportunity titled "ImPlementation REsearCh to DEvelop Interventions for People Living with HIV (PRECluDE) (U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.840.
- This funding opportunity was created on May 12, 2017.
- Applicants must submit their applications by Aug 07, 2017. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $500,000.00 in funding.
- The number of recipients for this funding is limited to 5 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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